KMID : 1130620190150020228
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Journal of Clinical Neurology 2019 Volume.15 No. 2 p.228 ~ p.234
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Conjugate Eye Deviation in Unilateral Lateral Medullary Infarction
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Teufel Julian
Strupp Michael Linn Jennifer Kalla Roger Feil Katharina
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Abstract
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Background and Purpose: The initial diagnosis of medullary infarction can be challenging since CT and even MRI results in the very acute phase are often negative.
Methods: A retrospective, observer-blinded study of horizontal conjugate eye deviation was performed in 1) 50 consecutive patients [age 58¡¾15 years (mean¡¾SD), 74% male, National Institutes of Health Stroke Scale 2¡¾1] with acute unilateral lateral medullary infarction as seen in MRI (infarction group), 2) 54 patients with transient brainstem symptoms [transient ischemic attack of brainstem (TIA) group; age 69¡¾16 years, 59% male], and 3) 53 patients (age 59¡¾20 years, 49% male) with diagnoses other than stroke (control group).
Results: Conjugate eye deviation was found in all patients in the infarction group [n=47 (94%) with ipsilesional deviation and n=3 (6%) with contralesional deviation] compared to 41% (n=22) in the brainstem TIA group and 15% (n=8) in the control group (p<0.0001). Within all groups mean deviation and range were similar for both sides (to the right vs. to the left side 26.6¡Æ¡¾12.3 vs. 26.1¡Æ¡¾12.3 in the infarction group, 10.5¡Æ¡¾5.8 vs. 8.4¡Æ¡¾6.3 in the brainstem TIA group and 4.5¡Æ¡¾3.2 vs. 7.5¡Æ¡¾3.2 in the control group). The extent of eye deviation was significantly greater in the infarction group (p<0.05).
Conclusions: All patients with MRI-demonstrated unilateral medullary infarction showed conjugate eye deviation. Therefore, conjugate eye deviation in patients with suspected acute lateral medullary infarction is a helpful sensitive sign for supporting the diagnosis, particularly if the deviation is >20¡Æ.
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KEYWORD
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dorsolateral medullary syndrome, eye motility disorders, cerebral stroke, transient ischemic attack, neurological examination, orthoptics
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